Netflix lands multi-year subscription exclusive for New Girl

While Netflix has scored some coups in original content, it has arguably been slacking on deals for conventional TV shows -- Amazon has landed numerous exclusives on that front in recent months. Netflix may be making up for lost time, however, with a multi-year subscription exclusive in the US for Fox's New Girl. Effective immediately, customers can stream the Zooey Deschanel comedy's first season; further seasons will come online as they finish their initial TV runs. We doubt that New Girl by itself will lead to many converts from other services, but its presence on Netflix proves that Amazon can't let its guard down.

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Source: http://www.engadget.com/2013/07/02/netflix-lands-multi-year-subscription-exclusive-for-new-girl/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Hijacking stress response in cancer

Public release date: 2-Jul-2013
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Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health

Scientists determine novel regulation of metabolic pathways in cancer

Cancer cells have alteration in metabolic pathways as a result of oncogenes that promote tumor growth. NRF2 (nuclear factor erythroid-derived 2-related factor 2) works as a "master gene" that turns on stress response by increasing numerous antioxidants and pollutant-detoxifying genes to protect the lungs from variety of air pollutants such as diesel exhaust and cigarette smoke. However, researchers at the Johns Hopkins Bloomberg School of Public Health and others have found for the first time that NRF2 signaling also plays a role in the growth of tumor cells by altering metabolic pathways. The study is published in the July issue of the Journal of Clinical Investigation.

"Previously, we had reported that lung cancer cells, due to mutation in inhibitors of NRF2, hijack the stress response pathway to cause chemoresistance," said Shyam Biswal, PhD, lead investigator of the study and professor in the Department of Environmental Health Sciences at the Bloomberg School of Public Health. "With our latest study, we show how the NRF2 pathway reprograms glucose metabolism, leading to increased energy production and tumor cell proliferation. A better understanding of this process could lead to potential cancer treatments."

The Johns Hopkins study demonstrated an important and previously unrecognized role for the NRF2 transcription factor in regulating cell metabolism. Specifically, NRF2 regulates genes miR-1 and miR-206 to "reprogram" glucose metabolism through PPP (pentose phosphate pathway) and the TCA (tricarboxylic acid) cycle, and fatty acid synthesis. The study demonstrated that these enzyme pathways, working together in specific patterns, stimulated tumor growth. The researchers validated their findings through a series of in vitro experiments and studies involving mice.

"Although Nrf2 has been extensively studied as a target for chemoprevention, recent work from our group and others have highlighted the idea of developing inhibitors of Nrf2 to inhibit cancer " said Anju Singh, PhD, lead author of the study and assistant scientist in the Bloomberg School's Department of Environmental Health Sciences. Using an integrated genomics and 13C-based metabolic flux system wide association analysis, we demonstrate that Nrf2 modulates glucose flux through PPP and TCA cycles in cancer cells. Biswal concludes that "This study reinforces the idea that targeting Nrf2 with small molecule inhibitors will starve the cancer cells by affecting metabolic pathways as well as decrease antioxidants and detoxification genes to intervene in therapeutic resistance." Biswal's group has been working with the National Center for Advancing Translational Sciences at NIH to develop Nrf2 inhibitors for cancer therapy.

###

"Transcription factor NRF2 regulated miR-1 and miR-206 to drive tumorigenesis" The study involved laboratories from the Johns Hopkins Center for Cancer Research, the National Cancer Institute, the Massachusetts College of Pharmacy, the Dana-Farber Cancer Institute, UCLA and the University of Maryland School of Medicine.

Funding for the research was provided by the National Institutes of Health grant, National Cancer Institute grants RO1 CA140492, P50 CA058184, P30CA006973 and National Institute of Environmental Sciences P30ES03819 and clinical innovator award from the Flight Attendants Medical Research Institute.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 2-Jul-2013
[ | E-mail | Share ]

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health

Scientists determine novel regulation of metabolic pathways in cancer

Cancer cells have alteration in metabolic pathways as a result of oncogenes that promote tumor growth. NRF2 (nuclear factor erythroid-derived 2-related factor 2) works as a "master gene" that turns on stress response by increasing numerous antioxidants and pollutant-detoxifying genes to protect the lungs from variety of air pollutants such as diesel exhaust and cigarette smoke. However, researchers at the Johns Hopkins Bloomberg School of Public Health and others have found for the first time that NRF2 signaling also plays a role in the growth of tumor cells by altering metabolic pathways. The study is published in the July issue of the Journal of Clinical Investigation.

"Previously, we had reported that lung cancer cells, due to mutation in inhibitors of NRF2, hijack the stress response pathway to cause chemoresistance," said Shyam Biswal, PhD, lead investigator of the study and professor in the Department of Environmental Health Sciences at the Bloomberg School of Public Health. "With our latest study, we show how the NRF2 pathway reprograms glucose metabolism, leading to increased energy production and tumor cell proliferation. A better understanding of this process could lead to potential cancer treatments."

The Johns Hopkins study demonstrated an important and previously unrecognized role for the NRF2 transcription factor in regulating cell metabolism. Specifically, NRF2 regulates genes miR-1 and miR-206 to "reprogram" glucose metabolism through PPP (pentose phosphate pathway) and the TCA (tricarboxylic acid) cycle, and fatty acid synthesis. The study demonstrated that these enzyme pathways, working together in specific patterns, stimulated tumor growth. The researchers validated their findings through a series of in vitro experiments and studies involving mice.

"Although Nrf2 has been extensively studied as a target for chemoprevention, recent work from our group and others have highlighted the idea of developing inhibitors of Nrf2 to inhibit cancer " said Anju Singh, PhD, lead author of the study and assistant scientist in the Bloomberg School's Department of Environmental Health Sciences. Using an integrated genomics and 13C-based metabolic flux system wide association analysis, we demonstrate that Nrf2 modulates glucose flux through PPP and TCA cycles in cancer cells. Biswal concludes that "This study reinforces the idea that targeting Nrf2 with small molecule inhibitors will starve the cancer cells by affecting metabolic pathways as well as decrease antioxidants and detoxification genes to intervene in therapeutic resistance." Biswal's group has been working with the National Center for Advancing Translational Sciences at NIH to develop Nrf2 inhibitors for cancer therapy.

###

"Transcription factor NRF2 regulated miR-1 and miR-206 to drive tumorigenesis" The study involved laboratories from the Johns Hopkins Center for Cancer Research, the National Cancer Institute, the Massachusetts College of Pharmacy, the Dana-Farber Cancer Institute, UCLA and the University of Maryland School of Medicine.

Funding for the research was provided by the National Institutes of Health grant, National Cancer Institute grants RO1 CA140492, P50 CA058184, P30CA006973 and National Institute of Environmental Sciences P30ES03819 and clinical innovator award from the Flight Attendants Medical Research Institute.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-07/jhub-hsr070213.php

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Rays' Moore blanks Astros for 11th win of season

By KRISTIE RIEKEN

AP Sports Writer

Associated Press Sports

updated 11:49 p.m. ET July 1, 2013

HOUSTON (AP) - Tampa Bay's Matt Moore shut down Houston on Monday night for his 11th win.

The Rays are impressed with his performance thus far, but believe the 24-year-old can do much more.

Moore allowed two hits in seven scoreless innings, and Ryan Roberts homered twice to give the Rays a 12-0 win over the Astros.

"He's going to continue to get better," manager Joe Maddon said. "That's his 11th win right there and we're still talking about the little foibles that he may have, yes. But to his credit he knows that and he knows that there's room for improvement, and because he does he's going to continue to get better."

Moore (11-3) won his third straight decision and Cesar Ramos pitched two perfect innings to complete the two-hitter and help the Rays win their third in a row.

He credited a lot of his success on Monday to his curveball.

"Yeah it was pretty good," he said. "It was definitely one of those things I could use later in the count pretty consistently without fear."

Roberts made it 3-0 with a two-run homer in the third inning off Dallas Keuchel (4-5) and tacked on another run with a solo shot in the eighth inning. It was his second two home run game of the season and the third of his career.

"We know everybody can hit on this team, and to see the guys come out and do it tonight, it was awesome to be a part of," Roberts said.

Sean Rodriguez had a career-high four hits - two doubles - with three RBIs and three other Rays added three hits apiece on a night they tied a season high in scoring and finished with 17 hits.

Chris Carter and Jake Elmore got Houston's only hits with singles as the last-place Astros dropped their fourth game in a row.

"It was just a tough, frustrating game watching them score the runs and just being on defense all day and watching it happen," Carter said. "Moore was tough today ... A lot of quick innings out of him and then we were on defense for a long time. It makes it tough."

Moore, who moved into a tie for second in wins among AL pitchers, struck out nine and walked three to tie his win total from last season when he finished 11-11.

Keuchel yielded eight hits and five runs with five walks in 4 2-3 innings. Paul Clemens couldn't slow the Rays down either, allowing five hits and four runs over the next two innings.

Wil Myers walked to start the third before a double by Ben Zobrist. The Rays took a 1-0 lead on a sacrifice fly by James Loney with one out and Roberts extended the lead to 3-0.

Yunel Escobar drew a one-out walk in the fifth and Ryan Roberts singled with two outs. Jose Lobaton's groundball single scored Escobar to make it 4-0. Sam Fuld's RBI single left Tampa Bay up 5-0 and chased Keuchel.

Houston didn't get a hit until Elmore singled with two outs in the third. But Moore struck out Jose Altuve to end that inning.

He got into a bit of trouble in the fourth when Jason Castro walked with no outs before advancing to third on a single by Carter. He escaped the jam by striking out J.D. Martinez before Matt Dominguez grounded into a double play.

Moore sat down the next nine batters he faced before being replaced by Ramos for the eighth inning.

"I think we just kind of got on rhythm and got on a good pace," Moore said. "There were a lot of strike ones which we followed up with strike two. We weren't trying to mess around too much tonight."

Loney extended his hitting streak to 12 games with a one-out single in the seventh. The Rays then hit five consecutive singles, with the last four driving in a run each, to push the lead to 9-0. The Astros replaced Clemens with Hector Ambriz after the fourth hit in that stretch, but the trouble didn't end.

Ambriz allowed the fifth single before walking Zobrist to load the bases. Houston finally got out of the inning when Escobar, the 10th batter of the inning, grounded out.

NOTES: Tampa Bay 3B Evan Longoria was out of the lineup for the third straight game with plantar fasciitis in his right foot, but the Rays don't plan on placing him on the disabled list. He took ground balls before the game Monday. Maddon said he felt better on Monday and they hope he can play sometime in the four-game series in Houston. "It's still a day by day situation," he said. "We think that we might be able to get him back somehow, some way. We'll just wait and see. But overall, not so bad."... AL Cy Young winner David Price is scheduled return from his first-ever stint on disabled list and start for the Rays on Tuesday. He has missed 44 games with a left triceps strain. Maddon said he'll be more concerned with how Price feels on Tuesday than in the results. "If we could get six innings out of him that would be outstanding," Maddon said. "Primarily let's just wish him good health and the fact that we're beyond the problem. Because if he stays well and is able to pitch on a regular basis, he's going to put up good numbers."... The Astros expect 1B/DH Carlos Pena to be back with the team on Tuesday after he missed two games to be with his family in the Dominican Republic following the drowning death of his nephew. ... SS Carlos Correa, the No. 1 overall pick in the 2012 draft by Houston, was picked for the last spot on the World Team roster for the 2013 All-Star Futures game by winning a fan vote. He is hitting .323 for Class A Quad Cities.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Righting the ship

Posnanski: There is no reason for the Pittsburgh Pirates to be atop Major League Baseball right now. They look like the same old Pirates. But everything has gone right for them this year. Now how long will it all last?

Source: http://nbcsports.msnbc.com/id/52371056/ns/sports-baseball/

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Pacifica shark attack: why we don't need to be afraid

Pacifica shark attack: Shark attacks are on the rise, but odds of becoming a shark attack victim are still very close to nil.

By Elizabeth Barber,?Contributor / June 27, 2013

A great white shark near Mexico drags buoys after taking bait.

Chris Ross/Chris Fischer/National Geographic Channel

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A shark attacked a kayaker near Pacifica State Beach in Pacifica, Calif., on Tuesday, the latest victim in a rising tally of shark attacks that likely has less to do with burgeoning shark aggression and more to do with more aggressive media coverage of shark incidents.

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The victim, Micah Flansburg, was fishing some 100 yards off from the beach at 3:30 p.m. when a Great White shark rose up under the boat and then took it in its teeth. The man was frightened, but unharmed.

"It was intense. It was just like the Discovery Channel where you see the eyes roll to the back of the head and the pink gums and his teeth bared," Mr. Flansburg told ABC.

Shark attack news reached a decade high in 2012, with about 80 unprovoked shark attack reports?worldwide, seven of which were fatal. Some eight of those attacks were off the US Pacific coast and another 26 were in Florida, the state that accounts for about half of all shark attacks in the United States, mostly because that state?s appealing beaches are so heavily trafficked. North America as a whole also accounts for about half of all shark attacks worldwide, but researchers are unsure what combination of meteorological, oceanographic, economic, and social factors are to blame for that trend.

Attacks that are considered provoked, such as when a shark attacks someone trying to pet or fish it, are not included in those tallies. Attacks on already drowned humans are also not included.

On the whole, shark attacks have been on an upswing over the last century, but scientists have said that those worrying numbers are largely due to increased efforts to document those incidents. Rates have also climbed as people spend more recreational time in the water, especially so in remote areas where sharks once reigned supreme. Other factors in shark attacks, such as climate change, have not yet been adequately studied to be linked to climbing reports of attack rates.

Some 60 percent of all shark attacks are on surfers, since that category of water users are more likely to be in the surf zone, where sharks sometimes lurk. Surfers are also more likely than swimmers to be kicking up water and alerting sharks to their presence.

In the event of a shark attack, scientists at the Florida Museum of Natural History recommend an aggressive response, like hitting its snout or clawing at its eyes or gills.

But that?s a tip we?re unlikely to ever need to use. The odds of becoming a shark attack victim, based on beach attendance rates in the US, is about one in 11.5 million. The odds of dying in an attack are about 0 in 264.1 million ? or, about nil.?

For perspective:

Odds of getting crushed by a vending machine are about 1 in 112 million.

Odds of becoming president are 1 in 10 million.

Odds of dating a supermodel are 1 in 88,000.

Odds of finding a pearl in an oyster are 1 in 12,000.

Odds are, these things are more likely to happen to you than a fatal shark attack.

Odds are, though, none of these things will happen to you.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/BJ7xfWMb5N8/Pacifica-shark-attack-why-we-don-t-need-to-be-afraid

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Son of former Ginebra import projected as top pick in NBA draft next year

Coming into the 2013 NBA draft, there was no consensus for the top overall pick, leading to shock when the Cleveland Cavaliers announced they were selecting Canadian forward Anthony Bennett of University of Nevada Las Vegas.

The Cavaliers? selection threw the draft into disarray as they passed on a trio of prospects tabbed by analysts as potential No. 1 choices ? Nerlens Noel of Kentucky, Ben McLemore of Kansas, and Alex Len of Maryland.

Len was drafted fifth by the Phoenix Suns, while Noel slipped to sixth to the New Orleans Pelicans, who then traded him to the Philadelphia 76ers. McLemore ended up with the Sacramento Kings at No. 7.

There figures to be far fewer questions next year, with current college freshman prospect Andrew Wiggins projected to be the consensus top overall pick.

He is the son of former Houston Rockets guard Mitchell Wiggins, who played for a Ginebra team carrying the Tonde?a banner in 1994. The elder Wiggins highlighted his PBA stint with a 78-point effort against Sta. Lucia that season.

But the younger Wiggins, who was born and raised in Canada, has quickly made a name for himself in basketball circles. He won the Naismith Prep Player of the Year Award and the Gatorade National Player of the Year as a high school senior.

He will be joining the Kansas Jayhawks for the upcoming United States NCAA season, but his stay on campus is expected to be a short one with the NBA knocking on his door.

The DraftExpress website has had the 6-foot-8 Wiggins as its top pick in its 2014 mock draft for months, calling him ?one of the best athletes you?ll find in the world outside of the NBA.?

Veteran sports marketing executive Sonny Vacarro, best known for signing Michael Jordan to his first Nike contract and organizing top high school basketball camps in the world, called Wiggins ?the anointed one? in an interview with Adam Zagoria of SportsNet New York.

?Everybody knows how good he is,? said Vacarro of Wiggins. ?If he doesn?t hurt himself while he?s in college, physically or mentally or whatever, he?s got it locked.?

Source: http://www.interaksyon.com/interaktv/son-of-former-ginebra-import-projected-as-top-pick-in-nba-draft-next-year

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Microsoft Thought They Owned Donkey Kong When They Acquired Rare

Conker?s Bad Fur Day director, Chris Seavor, has revealed that Microsoft mistakenly thought they owned the Donkey Kong franchise when they purchased Rare back in 2002. The information came about when Seavor was asked?where the Xbox One?s equivalent of PlayStation 4 exclusive Knack was. Seavor then told the tale about Microsoft and Donkey Kong. Here?s what he had to say.

The current generation of ?enablers? won?t even know they own the IP? Here?s a true story.. When Rare was first bought by MS a group of execs came on a tour.. One of them noticed the Donkey Kong. ..Posters everywhere and said.. ?Hey that?s great.. We own Donkey Kong right??? ???/massivesigh

Source: http://mynintendonews.com/2013/06/30/microsoft-thought-they-owned-donkey-kong-when-they-acquired-rare/

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Community, Needs, Design: Re-Thinking Approaches to Development

Sunday, June 30, 2013
2:00 pm - 4:00 pm, UCLA Hammer Museum - Billy Wilder Theater

Hammer Lectures

See below for additional information.

Admission

Free and open to the public.

Contact

UCLA Hammer Museum
(310) 443-7000
mnewcomer@hammer.ucla.edu

Website

http://hammer.ucla.edu/calendar/detail/type/program/id/...

Additional Information

Architecture firms Koning/Eizenberg and Michael Maltzan present their projects for underserved communities followed by a discussion on how for-profit development can learn from the nonprofit world.

Participants include Julie Eizenberg, Michael Maltzan, Victor Regnier, and moderator Nicholas Olsberg.

Visionary Development: Design Strategies for Better Living This series of six talks ties together themes of public and private real estate development in Southern California. In conjunction with A. Quincy Jones: Building for Better Living.

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Pacific Standard Time Presents: Modern Architecture in L.A. Design Strategies for Better Living is presented as part of Pacific Standard Time Presents: Modern Architecture in L.A. This collaboration, initiated by the Getty, brings together seventeen local cultural institutions from April through July for a wide-ranging look at the postwar built environment of the city as a whole, from its famous residential architecture to its vast freeway network, revealing the city?s development and ongoing impact in new ways.

Source: http://feedproxy.google.com/~r/uclahappenings-all-30days/~3/daMJNLPHf40/103512

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